Cystinuria is congenital in dogs where the issue is more common. Cystinuria is more common in Newfoundlands, Labradors, and Scottish Deerhounds. However, it can take many years for the crystals/stones to form in order that symptoms present themselves. Sometimes symptoms do not present themselves.
Unlike other bladder stones, cystine stones will not generally dissolve or breakdown with treatment. There are some drugs that can be given to try and break down the stones. These drugs are risky and are expensive. Drugs are not typically advised unless there are no other options. Generally, the stones are removed surgically.
In Basenjis, the symptoms may present at 17 months-11 years old. Cystinuria has been known in Basenjis for a long time. It is mentioned in the Complete Basenji by Elspet Ford. Although cases are rare this issue seems to be on the increase.
Mode of Inheritance The mode of inheritance in Newfoundlands and Labradors is autosomal recessive. However, there is evidence pointing to the mode of inheritance being autosomal recessive with incomplete penetrance. That is a trigger is thought to be required for dogs predisposing of cystinuria to develop stones. The mode of inheritance in other breeds, although thought to be autosomal recessive, is not confirmed. The University of Pennsylvania are researching this issue in dogs and cats.
- obvious pain when attempting to urinate;
- poor urine flow;
- blood in the urine;
- a fowl rotten egg smell to the urine due to the presence of cystine crystals;
- dogs become despondent;
- walk with back arched due to pain in the kidney location; and/or
- cannot pass urine due to a blockage (this needs immediate veterinary treatment)
In cases where a dog is diagnosed with this condition but is not presenting:
- crystals and/or stones;
- problems urinating; and/or
- signs of pain or discomfort;
Once diagnoses the prognosis is generally good. A change of diet is generally recommended. Further testing might be required to ensure that stones do not form. Once removed stones can re-form so continued observation is required.
It seems that most Basenji males block with this condition in the winter months. Basenji males have a season in the Autumn. Basenjis do not tend to drink as much coupled with the holding on (to mark) during the breeding season allows for the urine to be ultra-concentrated during the breeding season. The concentration of urine to any dog predisposed for this issue (has a genetic predisposition) allows for the formation of cystine crystal which then in turn form stones. It is thought that the formation of crystals and stone can take place within a few months hence blockages occur during the winter months. The fact that most Basenjis are house dogs and will hold-on as long as possible because they prefer not to go outside in the cold could also be a factor in the concentration of urine.
Although there is no known prevention as such. Keeping male Basenjis hydrated before, during and after the breeding season may assist with preventing the issue in any that may be predisposed for it. Most Basenjis who have blocked were also fed a kibble diet. Feeding a raw based diet where water can be added to the food to increase the water consumption and therefore the hydration of the dog may also be of some benefit.
It is a good idea for owners to watch all males urinate at least once per day. If the flow is strong then the dog is fine. If the flow is not strong and the dog looks laboured then further observation will be required - remember that during the breeding season Basenjis will urinate a little bit a lot - it is not the amount that is important it is if it's a good stream or a dripping trickle that is important to observe. If the Basenji is generally clean, as most males are, and you notice that his bedding is damp or wet with urine in the morning - observe the Basenji urinating.
Should your Basenji try to urinate and no urine presents and the dog is obviously trying but is unable to go and is uncomfortable the dog may have blocked. If so this is a medical emergency. You need to get your Basenji to the vet immediately. If you do not act quickly this can be a fatal condition.
Tambuzi Health Management Program – Canine Cystinurea
Cystinuria has not been seen in the breed for some time until recently cases were relatively rare. There seems to be a reoccurrance of this health concern over the past 4-5 years with social media pinpointing more Basenjis blocking from this issue. It seems likely that the issue is hereditary, however, the mode of inheritance is unknown at this stage and there is limited opportunity to screen dogs for it as a preventative measure.
- Mandatory: Consideration must be given to any breeding where there is thought to be (confirmed or not confirmed) cystinurea in the pedigree.