Immunoproliferative Small Intestinal Disease (IPSID) is a disease that is known by a number of other names; malabsorption, diarroeal syndrome, immunoproliferative enteropathy. In Basenjis in particular, a hereditary lymphocytic-plasmacytic enteritis has been identified. The mode of inheritance is unknown. The disease is now rare in Basenjis. It is possible that the disease is autosomal recessive with incomplete penetrance. Other factors, triggers, maybe required for symptoms in Basenjis that are 'predisposed' to the condition to present themselves. A dietary factor could be required ti 'trigger' the disease.
Usually IPSID is seen in young adult to middle aged Basenjis. Generally it starts with loss of appetite followed by bouts of sever diarrhoea. The trigger for Basenji predisposed to this condition may be stress related. A stressful event such a travel or boarding may 'bring on' the disease. Weight loss is common due to loss of nutrients and protein from the gut.
- weight loss;
- increased and decreased appetite;
- skin lesions;
- hyperpigmentation of the ears and thickening of the ear leather;
- hairloss in the ear and on the stomach;
- lethargy and/or depression.
Generally, diagnosis is not simple. There are many diseases and issues that cause the symptoms. A process of elimination and/or several diagnosis processes are employed; blood (serum protein levels, low albumin, high globulin and high IgA levels) tests and fecal tests can rule out some other issues such as parasites and bacterial infections. A biopsy is one of the most important diagnosis tools. Other possible causes of the symptoms including gardia and food allergies should be ruled out.
There is no cure for the condition. IPSID can be controlled if caught early. Diet may need to be changed. Prednisone can be used in a treatment regime starting at a high dose and the gradually reducing the dose. Prednisone suppresses the hyperactive immune response and decreases inflammation.
Tambuzi Health Management Program – IPSID
Mandatory: Any Basenji diagnosed with Immunoproliferative Small Intestinal Disease IPSID is not to be bred from.